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Abstract #1463

Perfluorohexane liquid MRI of mouse lungs in a dual-tuned 1 H/ 19 F coil

Alexandr A Khrapitchev 1 , James R Larkin 1 , Stavros Melemenidis 1 , Konstantinos Papoutsis 2 , Peter Thelwall 3 , and Nicola R Sibson 1

1 CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2 Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 3 Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle, United Kingdom

The imaging of lungs with MRI is difficult owing to low proton density. Imaging with hyperpolarized noble gases has overcome some of these limitations but at great expense and effort. We have implemented imaging of mouse lungs using 19F MRI of perfluorohexane a cheap biocompatible liquid at room temperature. Using lungs filled with perfluorohexane, we were able to obtain high resolution 2D and 3D scans with comparable SNRs to hyperpolarized xenon imaging and high resolution. These bright and stable lung images may provide a useful background for imaging contrast agents that work through production of hypointensities on T2* weighted images.

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