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Abstract #1468

Ultrashort echo time magnetic resonance imaging of the lung using a high-relaxivity T1 blood-pool contrast agent

Joris Tchouala Nofiele 1 , Weiran Cheng 2 , Inga E Haedicke 2 , Tameshwar Ganesh 1 , Xiao-an Zhang 2 , and Hai-Ling Margaret Cheng 1,3

1 Hospital for Sick Children, Toronto, Ontario, Canada, 2 Chemistry, University of Toronto, Toronto, Ontario, Canada, 3 Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

The lung is one of the most challenging organs to image due to intrinsic rapid signal decay. Here we demonstrate proof-of-concept for a new MRI approach to achieve substantial gains in signal-to-noise (SNR): contrast-enhanced ultrashort echo time (UTE) imaging following intravenous injection of a high-relaxivity blood-pool manganese porphyrin T1 contrast agent. The new agent increased relative enhancement of lung parenchyma by over 10-fold compared to Gd-DTPA, and UTE boosted SNR by a factor of 4 over conventional acquisitions. The new agent maintained steady enhancement over at least 60 minutes, thus providing a long time window for obtaining high-resolution, high-quality images.

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