Abstract #1468
Ultrashort echo time magnetic resonance imaging of the lung using a high-relaxivity T1 blood-pool contrast agent
Joris Tchouala Nofiele 1 , Weiran Cheng 2 , Inga E Haedicke 2 , Tameshwar Ganesh 1 , Xiao-an Zhang 2 , and Hai-Ling Margaret Cheng 1,3
1
Hospital for Sick Children, Toronto,
Ontario, Canada,
2
Chemistry,
University of Toronto, Toronto, Ontario, Canada,
3
Institute
of Biomaterials & Biomedical Engineering, University of
Toronto, Toronto, Ontario, Canada
The lung is one of the most challenging organs to image
due to intrinsic rapid signal decay. Here we demonstrate
proof-of-concept for a new MRI approach to achieve
substantial gains in signal-to-noise (SNR):
contrast-enhanced ultrashort echo time (UTE) imaging
following intravenous injection of a high-relaxivity
blood-pool manganese porphyrin T1 contrast agent. The
new agent increased relative enhancement of lung
parenchyma by over 10-fold compared to Gd-DTPA, and UTE
boosted SNR by a factor of 4 over conventional
acquisitions. The new agent maintained steady
enhancement over at least 60 minutes, thus providing a
long time window for obtaining high-resolution,
high-quality images.
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