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Abstract #1469

3D Ultrashort TE (UTE) MRI repeatability within the thorax and its application to pulmonary fibrosis.

Alexander Weller 1 , Sharon L Giles 2 , Veronica A Morgan 2 , David Collins 1 , David M Higgins 3 , and Nandita M de-Souza 1

1 CRUK Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom, 2 MRI Department, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 3 Clinical Science, Philips Healthcare, Guildford, Surrey, United Kingdom

T2* quantification within lung parenchyma using Ultra-short time to echo (UTE) MRI has previously been shown to correlate with pulmonary fibrosis in mice and CT density in humans. Here, T2* values are reported for patients with lung carcinoma, from MRI studies performed pre and post radiotherapy. Repeatability of T2* values within tumor and surrounding lung are confirmed before demonstrating: (a) T2* values for fibrotic lung and; (b) change in T2* following radiotherapy. The results reflect the potential for UTE MRI in both early identification of pulmonary fibrosis and in differentiating fibrosis from pneumonitis on CT.

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