3D Ultrashort TE (UTE) MRI repeatability within the thorax and its application to pulmonary fibrosis.
Alexander Weller 1 , Sharon L Giles 2 , Veronica A Morgan 2 , David Collins 1 , David M Higgins 3 , and Nandita M de-Souza 1
CRUK Cancer Imaging Centre, Institute of
Cancer Research, Sutton, Surrey, United Kingdom,
Department, Royal Marsden Hospital, Sutton, Surrey,
Science, Philips Healthcare, Guildford, Surrey, United
T2* quantification within lung parenchyma using
Ultra-short time to echo (UTE) MRI has previously been
shown to correlate with pulmonary fibrosis in mice and
CT density in humans. Here, T2* values are reported for
patients with lung carcinoma, from MRI studies performed
pre and post radiotherapy. Repeatability of T2* values
within tumor and surrounding lung are confirmed before
demonstrating: (a) T2* values for fibrotic lung and; (b)
change in T2* following radiotherapy. The results
reflect the potential for UTE MRI in both early
identification of pulmonary fibrosis and in
differentiating fibrosis from pneumonitis on CT.
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