Can baseline T1-DCE-MRI perfusion and permeability parameters predict concurrent chemoradiotherapy response in patients of NSCLC?
Xiuli Tao 1 , Han Ouyang 1 , Li Liu 1 , Feng Ye 1 , Ying Song 1 , Xiao Xu 2 , Zihua Su 2 , and Ning Wu 1
Department of Diagnostic Radiology, Cancer
Hospital Chinese Academy of Medical Sciences, Beijinh,
Healthcare, Beijing, China
DCE-MRI has been extensively used in monitoring
treatment response on many anatomies. However, this
technique was not fully explored in lung cancer due to
breathing motion. By using a mutual information
non-rigid registration method to eliminate body motion
and using modified Tofts Model and de-convolution
method, clinical relevant parameters could be extracted
from a breath-hold DCE-MRI to monitor treatment response
on NSCLC patients.
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