Abstract #1472
Imaging chronic rejection in mouse lung allografts with 1 H MRI
Jinbang Guo 1,2 , Xingan Wang 3 , Anne K. Perl 4 , Zackary I. Cleveland 1 , Randy Giaquinto 5 , Andrew E. Gelman 3 , and Jason C. Woods 1,2
1
Center for Pulmonary Imaging Research,
Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, United States,
2
Department
of Physics, Washington University in St. Louis, St.
Louis, MO, United States,
3
Department
of Surgery, Washington University in St. Louis, St.
Louis, MO, United States,
4
Division
of Pulmonary Biology, Cincinnati Children's Hospital
Medical Center, Cincinnati, OH, United States,
5
Imaging
Research Center, Cincinnati Children's Hospital Medical
Center, Cincinnati, OH, United States
Lung transplantation is a life-saving treatment to many
end-stage lung diseases, but chronic rejection remains
the major barrier to the long-term survival of lung
transplant recipients and is not well understood. In
this study, we used triple transgenic mice
(Scgb1a1/DT-A) as donors in a mouse model of orthotopic,
left-lung lung transplantation to induce chronic
rejection similar to that in human lung allografts.
Ventilation-gated
1
H
MRI at 7T was performed with a 2-D short-TE GRE sequence
to quantitatively monitor the rejection and relate
individual outcomes with histological examination to
understand the timecourse of chronic rejection.
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