Abstract #1477
Pulmonary imaging of acute lung injury in mice with ZTE
Iga Muradyan 1 , Raja-Elie Abdulnour 2,3 , Angelos Kyriazis 1 , Samuel Patz 1 , and Bruce Levy 2,3
1
Department of Radiology, Brigham and Women's
Hospital, Harvard Medical School, Boston, MA, United
States,
2
Pulmonary
and Critical Care Medicine, Brigham and Womens
Hospital, Harvard Medical School, Boston, MA, United
States,
3
Center
for Experimental Therapeutics and Reperfusion Injury,
Department of Anesthesiology, Brigham and Womens
Hospital, Harvard Medical School, Boston, MA, United
States
Zero echo time (ZTE) was used to evaluate the
feasibility of performing high-resolution MRI of lung
during acute inflammation, with important translational
implications to evaluation of human acute lung
inflammation and its resolution. Despite the presence of
radial imaging artifacts, we were able to track relative
signal changes in control mice compared to 24- and 72-hr
post injury groups. Increased lung density at 24 hrs
compared to 0 and 72 hrs is observed, which correlates
with the time course of acid-induced acute lung injury,
with peak airway and left lung interstitial neutrophils
24 hrs after intra-tracheal acid.
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