Abstract #1479
Ultra-short echo time MRI Measurements of Emphysema using Principal Component Analysis
Khadija Sheikh 1,2 , Dante Capaldi 1,2 , Sarah Svenningsen 1,2 , David G McCormack 3 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Division
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
Pulmonary emphysema is defined as a progressive
condition of the lung characterized by abnormal and
permanent enlargement of the airspaces distal to the
terminal bronchioles, accompanied by the destruction of
their walls, and without obvious fibrosis. Pulmonary
emphysema has been quantified using mean signal
intensity and T2* measurements enabled by ultra-short
echo time (UTE)
1
H
MRI. We evaluated the
1
H
UTE frequency-signal intensity pairs to assess emphysema
using principal component analysis and showed in a small
group of ex-smokers with emphysema that PCA can be used
to derive a UTE MRI score that is related to RA
950
and
FEV
1
/FVC.
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