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Abstract #1479

Ultra-short echo time MRI Measurements of Emphysema using Principal Component Analysis

Khadija Sheikh 1,2 , Dante Capaldi 1,2 , Sarah Svenningsen 1,2 , David G McCormack 3 , and Grace Parraga 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada, 3 Division of Respirology, Department of Medicine, The University of Western Ontario, London, Ontario, Canada

Pulmonary emphysema is defined as a progressive condition of the lung characterized by abnormal and permanent enlargement of the airspaces distal to the terminal bronchioles, accompanied by the destruction of their walls, and without obvious fibrosis. Pulmonary emphysema has been quantified using mean signal intensity and T2* measurements enabled by ultra-short echo time (UTE) 1 H MRI. We evaluated the 1 H UTE frequency-signal intensity pairs to assess emphysema using principal component analysis and showed in a small group of ex-smokers with emphysema that PCA can be used to derive a UTE MRI score that is related to RA 950 and FEV 1 /FVC.

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