Integrated Spectroscopic Imaging (CSI) and Chemical Shift Saturation Recovery (CSSR) of Hyperpolarized 129 Xe in the Human Lungs

A method for assessment of regional changes in lung microstructure and gas-exchange with hyperpolarized ¹²⁹ Xe was implemented using an interleaved combination of spectroscopic imaging (CSI) and chemical shift saturation recovery (CSSR). ¹²⁹ Xe CSSR uptake curves demonstrated a strong anterior-posterior gradient in MR signal from dissolved and gaseous ¹²⁹ Xe in the lung. The method was validated by measuring the anterior-posterior gradient in ventilation-perfusion ratio using the ratio of signal intensities from ¹²⁹ Xe in the gas phase and dissolved in erythrocytes. The proposed method may be applicable to quantify regional variations in gas-exchange dynamics in interstitial pulmonary disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.