Abstract #1485
Integrated Spectroscopic Imaging (CSI) and Chemical Shift Saturation Recovery (CSSR) of Hyperpolarized 129 Xe in the Human Lungs
Neil James Stewart 1 and Jim Michael Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom
A method for assessment of regional changes in lung
microstructure and gas-exchange with hyperpolarized
129
Xe
was implemented using an interleaved combination of
spectroscopic imaging (CSI) and chemical shift
saturation recovery (CSSR).
129
Xe
CSSR uptake curves demonstrated a strong
anterior-posterior gradient in MR signal from dissolved
and gaseous
129
Xe in the lung. The method was
validated by measuring the anterior-posterior gradient
in ventilation-perfusion ratio using the ratio of signal
intensities from
129
Xe
in the gas phase and dissolved in erythrocytes. The
proposed method may be applicable to quantify regional
variations in gas-exchange dynamics in interstitial
pulmonary disorders.
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