Abstract #1486
Hyperpolarized 129 Xe Dissolved-Phase MR Spectroscopy in Mice Changes with Lung Cancer Progression
Rohan S Virgincar 1 , Simone Degan 2,3 , Matthew S Freeman 4 , Mu He 5 , and Bastiaan Driehuys 3
1
Biomedical Engineering, Duke University,
Durham, North Carolina, United States,
2
Center
for Molecular and Biomolecular Imaging, Duke University,
Durham, North Carolina, United States,
3
Radiology,
Duke University Medical Center, Durham, North Carolina,
United States,
4
Medical
Physics Graduate Program, Duke University, Durham, North
Carolina, United States,
5
Electrical
and Computer Engineering, Duke University, Durham, North
Carolina, United States
This study exploits the solubility of
129
Xe
in tissues and associated chemical shifts to study
pathological changes in the tissue microenvironment
accompanying lung tumor formation in mice. We acquired
hyperpolarized
129
Xe
spectra from both the FID and after a spin echo. Spin
echo spectra showed two unique peaks, belonging to
aqueous media and fat. The fat peak was dramatically
reduced and slightly broadened with increasing tumor
burden, estimated from histology. This may be a
signature of white adipose tissue browning, a hallmark
of cancer-associated cachexia.
129
Xe
MRI could thus provide a novel ionizing radiation-free
tool to study cachexia.
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