Abstract #1490
Optimal glass forming solvent and photo-induced radicals yield 129Xe hyperpolarization via sublimation-DNP to biomedical imaging standards
Andrea Capozzi 1 , Christophe Roussel 2 , Arnaud Comment 1 , and Jean-Noel Hyacinthe 3
1
Institute of Physics of Biological Systems,
EPFL, Lausanne, Vaud, Switzerland,
2
Section
of Chemistry and Chemical Engineering, Institute of
Chemical Sciences and Engineering, EPFL, Lausanne, Vaud,
Switzerland,
3
University
of Applied Sciences and Arts Western Switzerland,
Geneva, Switzerland
Despite unique biomedical applications from ventilation
to perfusion and molecular imaging, hyperpolarized (HP)
129Xe MRI suffers from the somehow limited availability
of HP 129Xe. Sublimation-DNP consists in producing HP
129Xe using a generic dissolution-DNP polarizer able to
produce various HP tracers. It can contribute to a wider
access to HP 129Xe and spread of its unique
applications. A limited polarization level was
precluding the potentially higher HP gas output. In the
present work we show how the combination of an optimal
glass-forming solvent with photo-induced radicals leads
to improved 129Xe polarization, and bring the technique
to the advanced biomedical imaging standards.
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