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Abstract #1490

Optimal glass forming solvent and photo-induced radicals yield 129Xe hyperpolarization via sublimation-DNP to biomedical imaging standards

Andrea Capozzi 1 , Christophe Roussel 2 , Arnaud Comment 1 , and Jean-Noel Hyacinthe 3

1 Institute of Physics of Biological Systems, EPFL, Lausanne, Vaud, Switzerland, 2 Section of Chemistry and Chemical Engineering, Institute of Chemical Sciences and Engineering, EPFL, Lausanne, Vaud, Switzerland, 3 University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland

Despite unique biomedical applications from ventilation to perfusion and molecular imaging, hyperpolarized (HP) 129Xe MRI suffers from the somehow limited availability of HP 129Xe. Sublimation-DNP consists in producing HP 129Xe using a generic dissolution-DNP polarizer able to produce various HP tracers. It can contribute to a wider access to HP 129Xe and spread of its unique applications. A limited polarization level was precluding the potentially higher HP gas output. In the present work we show how the combination of an optimal glass-forming solvent with photo-induced radicals leads to improved 129Xe polarization, and bring the technique to the advanced biomedical imaging standards.

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