129 Xe Dynamic Spectroscopy and Modelling: A Repeatability and Method Comparison Study

The intra-subject variability (repeatability) of quantitative parameters derived from the ¹²⁹ Xe chemical shift saturation recovery (CSSR) and red-blood-cell-to-tissue signal ratio (RBC-T/P) methods was evaluated to assess their sensitivity in identifying early-stage interstitial lung disease (ILD). Five healthy volunteers were scanned on three separate occasions using two implementations of the ¹²⁹ Xe CSSR sequence existing in literature. Intra-subject standard deviations and repeatability coefficients of CSSR-derived septal thickness and RBC-T/P ratio values were considerably less than previously-measured differences between normals and ILD patients. However, derived surface-area-to-volume ratio and capillary transit time parameters were substantially variable and cannot be considered as robust quantitative markers.

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