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Abstract #1492

Mapping 129 Xenon ADC of Radiation-Induced Lung Injury at Low Magnetic Field Strength Using a Sectoral Approach

Krzysztof Wawrzyn 1,2 , Alexei Ouriadov 1 , Elaine Hegarty 1 , Susannah Hickling 3 , and Giles Santyr 1,4

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Department of Medical Biophysics, Western University, London, Ontario, Canada, 3 Department of Medical Physics, McGill University, Montreal, Quebec, Canada, 4 The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada

Early diagnosis of radiation-induced lung injury following radiotherapy is critical for prevention of permanent lung damage. MRI of the apparent diffusion coefficient (ADC) of hyperpolarized xenon-129 gas shows promise for early measurement of RILI. A UTE sequence based on a pseudo non-Cartesian k-space trajectory (i.e. Sectoral) is implemented at low field (0.07 T) for efficient use of the non-renewable magnetization of xenon-129. A pilot study demonstrated Sectoral ADC mapping on healthy and 2-weeks post irradiated rats. A significant correlation between ADC and mean linear intercept from histology was observed and a separation between the cohorts was observed with FWHM ADC.

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