Abstract #1493
Effect of RF Pulse Repetition Time on Gas Transfer for Dissolved Hyperpolarized 129 Xe MRI
Brandon Zanette 1,2 , Matthew S Fox 3 , Ozkan Doganay 3,4 , Elaine Hegarty 2,3 , and Giles E Santyr 1,2
1
Department of Medical Biophysics, University
of Toronto, Toronto, Ontario, Canada,
2
Peter
Gilgan Centre for Research and Learning, The Hospital
for Sick Children, Toronto, Ontario, Canada,
3
Robarts
Research Institute, London, Ontario, Canada,
4
Department
of Medical Biophysics, University of Western Ontario,
London, Ontario, Canada
The non-renewable magnetization of hyperpolarized
129
Xe
gas typically allows for image acquisition to be as
quick as possible. However, when imaging the dissolved
phase (tissue, blood) of hyperpolarized
129
Xe,
signal strength is sensitive to the repetition time (TR)
between RF pulses. This is due to gas transfer into the
dissolved compartments and poses a problem similar to
allowing for sufficient T
1
recovery
in conventional proton MRI. In this work we examine the
effect of TR on dissolved phase
129
Xe
imaging and consider a simple, empirical method for
determining the optimum TR which balances signal
replenishment and time delay.
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