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Abstract #1493

Effect of RF Pulse Repetition Time on Gas Transfer for Dissolved Hyperpolarized 129 Xe MRI

Brandon Zanette 1,2 , Matthew S Fox 3 , Ozkan Doganay 3,4 , Elaine Hegarty 2,3 , and Giles E Santyr 1,2

1 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada, 3 Robarts Research Institute, London, Ontario, Canada, 4 Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada

The non-renewable magnetization of hyperpolarized 129 Xe gas typically allows for image acquisition to be as quick as possible. However, when imaging the dissolved phase (tissue, blood) of hyperpolarized 129 Xe, signal strength is sensitive to the repetition time (TR) between RF pulses. This is due to gas transfer into the dissolved compartments and poses a problem similar to allowing for sufficient T 1 recovery in conventional proton MRI. In this work we examine the effect of TR on dissolved phase 129 Xe imaging and consider a simple, empirical method for determining the optimum TR which balances signal replenishment and time delay.

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