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Abstract #1494

Regional Mapping of Gas Uptake by Lung Tissue and Blood in Subjects with COPD using Hyperpolarized Xenon-129 MRI

Kun Qing 1 , Talissa A. Altes 1 , Y. Michael Shim 1 , Nicholas J. Tustison 1 , Kai Ruppert 1,2 , Chengbo Wang 1,3 , Jaime F. Mata 1 , G. Wilson Miller 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler, III 1

1 University of Virginia, Charlottesville, VA, United States, 2 Cincinnati Children's Hospital, OH, United States, 3 The University of Nottingham Ningbo China, Zhejiang, China, 4 Xemed LLC, NH, United States, 5 University of New Hampshire, NH, United States

Hyperpolarized xenon-129 MRI is a useful tool to characterize lung function in COPD. In this study, we measured gas uptake of inhaled xenon-129 in 19 COPD subjects and 21 healthy controls, and correlated the results with xenon-129 ventilation, diffusion-weighted imaging, pulmonary function tests and exercise tolerance test. We found significant decrease of gas uptake and different patterns of functional alternations in COPD subjects as compared to healthy controls. The decrease of gas uptake appeared to be mostly correlated with emphysematous tissue destruction or enlargement of distal airways detected by xenon-129 diffusion weighted imaging, and not airflow obstruction.

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