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Abstract #1495

Investigation of an animal model of pulmonary fibrosis - ex vivo lung MRI using a perfluorocarbon compound as a contrast agent for hyperpolarized 129 Xe

Clementine Lesbats 1 , Anthony Habgood 2 , David ML Lilburn 3 , Joseph S Six 4 , Gisli Jenkins 2 , Galina E Pavlovskaya 1 , and Thomas Meersmann 1

1 Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2 School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3 Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, 4 Carestream Health Inc., White City, Oregon, United States

Gas phase hyperpolarized 129Xe imaging has been performed to compare the ventilation in control and fibrotic ex vivo lungs. The excised lungs blood was replaced by a perfluorocarbon fluid (PFC). Hyperpolarized 129Xe dissolved in PFC, resonating at a different chemical shift than the tissue and the gas phases, is used as a contrast agent to study the diffusion kinetics from the alveolar space, through the tissue, to the vasculature in fibrotic and control lungs. The selective destruction of the PFC signal preserves the tissue and gas phase signal, which can then provide insight into the tissue-blood diffusion properties.

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