Abstract #1495
Investigation of an animal model of pulmonary fibrosis - ex vivo lung MRI using a perfluorocarbon compound as a contrast agent for hyperpolarized 129 Xe
Clementine Lesbats 1 , Anthony Habgood 2 , David ML Lilburn 3 , Joseph S Six 4 , Gisli Jenkins 2 , Galina E Pavlovskaya 1 , and Thomas Meersmann 1
1
Sir Peter Mansfield Imaging Centre,
University of Nottingham, Nottingham, United Kingdom,
2
School
of Medicine, University of Nottingham, Nottingham,
United Kingdom,
3
Clinical
Research Imaging Centre, University of Edinburgh,
Edinburgh, United Kingdom,
4
Carestream
Health Inc., White City, Oregon, United States
Gas phase hyperpolarized 129Xe imaging has been
performed to compare the ventilation in control and
fibrotic ex vivo lungs. The excised lungs blood was
replaced by a perfluorocarbon fluid (PFC).
Hyperpolarized 129Xe dissolved in PFC, resonating at a
different chemical shift than the tissue and the gas
phases, is used as a contrast agent to study the
diffusion kinetics from the alveolar space, through the
tissue, to the vasculature in fibrotic and control
lungs. The selective destruction of the PFC signal
preserves the tissue and gas phase signal, which can
then provide insight into the tissue-blood diffusion
properties.
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