Abstract #1496
T2* and Frequency Shift Maps of Healthy and CF Subjects
Steven Guan 1 , Kun Qing 1 , Tally Altes 1 , John Mugler III 1 , Iulian Ruset 2,3 , Deborah Froh 1 , Grady Miller 1 , James Brookeman 1 , and Jaime Mata 1
1
University of Virginia, Charlottesville, VA,
United States,
2
University
of New Hampshire, NH, United States,
3
Xemed
LLC, NH, United States
Here, we present our preliminary data for comparing
healthy and cystic fibrosis (CF) subjects using a robust
dissolved phase fitting method for post processing
Xe-129 3D Single-Breath Chemical Shift Imaging (3D
SB-CSI) data. In addition to the Tissue/RBC maps, we are
now able to generate peak position and T2* maps for the
tissue and RBC components. Global averages for the peak
positions and T2* are similar to those reported in
literature. CF subjects had a lower RBC peak position
than healthy subjects. Having regional analysis of these
parameters presents new avenues for probing and
understanding lung physiology and disease progression.
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