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Abstract #1496

T2* and Frequency Shift Maps of Healthy and CF Subjects

Steven Guan 1 , Kun Qing 1 , Tally Altes 1 , John Mugler III 1 , Iulian Ruset 2,3 , Deborah Froh 1 , Grady Miller 1 , James Brookeman 1 , and Jaime Mata 1

1 University of Virginia, Charlottesville, VA, United States, 2 University of New Hampshire, NH, United States, 3 Xemed LLC, NH, United States

Here, we present our preliminary data for comparing healthy and cystic fibrosis (CF) subjects using a robust dissolved phase fitting method for post processing Xe-129 3D Single-Breath Chemical Shift Imaging (3D SB-CSI) data. In addition to the Tissue/RBC maps, we are now able to generate peak position and T2* maps for the tissue and RBC components. Global averages for the peak positions and T2* are similar to those reported in literature. CF subjects had a lower RBC peak position than healthy subjects. Having regional analysis of these parameters presents new avenues for probing and understanding lung physiology and disease progression.

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