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Abstract #1497

Hyperpolarized 129 Xe Imaging of the Lung using Spiral IDEAL

Ozkan Doganay 1,2 , Trevor Wade 2 , Elaine Hegarty 2 , Krzysztof Wawrzyn 2 , Rolf F. Schulte 3 , Charles McKenzie 1,2 , and Giles Santyr 2,4

1 Western University, London, Ontario, Canada, 2 Robarts Research Institute, London, Ontario, Canada, 3 GE Global Research, Munich, Germany, 4 Peter Gilgan Centre for Research and Learning, Toronto, Ontario, Canada

We implemented a spiral IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least-square estimation) approach for Hyperpolarized 129Xe Imaging of the Lung. The expected spatial resolution and SNR with respect to the readout time, Treadout, were calculated from the point spread function (PSF) and optimized for in vitro and in vivo imaging based on measured T2* values. This study shows that IDEAL-spiral approach is feasible for Hp 129Xe imaging of the rodent lung, providing an increase in normalized SNR of a factor of approximately four for the dissolved phase of Hp 129Xe in rat lungs.

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