Abstract #1497
Hyperpolarized 129 Xe Imaging of the Lung using Spiral IDEAL
Ozkan Doganay 1,2 , Trevor Wade 2 , Elaine Hegarty 2 , Krzysztof Wawrzyn 2 , Rolf F. Schulte 3 , Charles McKenzie 1,2 , and Giles Santyr 2,4
1
Western University, London, Ontario, Canada,
2
Robarts
Research Institute, London, Ontario, Canada,
3
GE
Global Research, Munich, Germany,
4
Peter
Gilgan Centre for Research and Learning, Toronto,
Ontario, Canada
We implemented a spiral IDEAL (Iterative Decomposition
of water and fat with Echo Asymmetry and Least-square
estimation) approach for Hyperpolarized 129Xe Imaging of
the Lung. The expected spatial resolution and SNR with
respect to the readout time, Treadout, were calculated
from the point spread function (PSF) and optimized for
in vitro and in vivo imaging based on measured T2*
values. This study shows that IDEAL-spiral approach is
feasible for Hp 129Xe imaging of the rodent lung,
providing an increase in normalized SNR of a factor of
approximately four for the dissolved phase of Hp 129Xe
in rat lungs.
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