Abstract #1498
Validation of 129 Xe diffusion MRI as a measure of airspace enlargement in human lungs
Robert Paul Thomen 1,2 , James D Quirk 3 , David Roach 1 , Tiffany Egan-Rojas 1 , Kai Ruppert 1 , Iulian Ruset 4 , Talissa Altes 5 , Dmitriy Yablonskiy 3 , and Jason C Woods 1,2
1
Center for Pulmonary Imaging, Cincinnati
Children's Hospital Medical Center, Cincinnati, OH,
United States,
2
Physics,
Washington University in St Louis, St Louis, MO, United
States,
3
School of Medicine, Washington
University in St Louis, St Louis, MO, United States,
4
XeMed,
LLC, Durham, NH, United States,
5
Radiology,
University of Virginia Hospital Medical Center, VA,
United States
3He diffusion MRI has been shown to be highly sensitive
to the micro-geometry of acinar ducts and alveoli. 129Xe
diffusion MRI has similar merit, despite greater
technical challenges, but its utility in probing
pulmonary microstructure requires validation by
comparison to the gold standard of histology. Here we
present the first direct comparisons of 129Xe diffusion
MRI to quantitative histology in human lungs, in order
to validate the imaging technique as a biomarker for
airspace enlargement in COPD and take steps toward
regulatory advancement. Our results show good
correlation between 129Xe ADC and mean linear intercept.
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