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Abstract #1498

Validation of 129 Xe diffusion MRI as a measure of airspace enlargement in human lungs

Robert Paul Thomen 1,2 , James D Quirk 3 , David Roach 1 , Tiffany Egan-Rojas 1 , Kai Ruppert 1 , Iulian Ruset 4 , Talissa Altes 5 , Dmitriy Yablonskiy 3 , and Jason C Woods 1,2

1 Center for Pulmonary Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2 Physics, Washington University in St Louis, St Louis, MO, United States, 3 School of Medicine, Washington University in St Louis, St Louis, MO, United States, 4 XeMed, LLC, Durham, NH, United States, 5 Radiology, University of Virginia Hospital Medical Center, VA, United States

3He diffusion MRI has been shown to be highly sensitive to the micro-geometry of acinar ducts and alveoli. 129Xe diffusion MRI has similar merit, despite greater technical challenges, but its utility in probing pulmonary microstructure requires validation by comparison to the gold standard of histology. Here we present the first direct comparisons of 129Xe diffusion MRI to quantitative histology in human lungs, in order to validate the imaging technique as a biomarker for airspace enlargement in COPD and take steps toward regulatory advancement. Our results show good correlation between 129Xe ADC and mean linear intercept.

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