Abstract #1504
Ventilation-Perfusion Analysis with Co-registered Hyperpolarized Gas and CE 1 H Perfusion MRI
Paul J.C. Hughes 1 , Bilal A. Tahir 1,2 , Felix C. Horn 1 , Helen Marshall 1 , Rob H. Ireland 1,2 , and James M. Wild 1
1
Academic Unit of Radiology, University of
Sheffield, Sheffield, South Yorkshire, United Kingdom,
2
Academic
Unit of Clinical Oncology, University of Sheffield,
Sheffield, South Yorkshire, United Kingdom
Multi-nuclear lung MRI can provide high spatial
resolution ventilation- and perfusion-weighted images,
but these are normally acquired in different RF coils
with the patient moved between acquisitions such that
the ventilation and perfusion images are not spatially
registered. This work proposes a semi-automated image
processing workflow, including registration, masking and
normalisation, for quantitative assessment of V/Q, and
demonstrates its utility on images acquired from
patients with moderate-to-severe asthma.
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