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Abstract #1504

Ventilation-Perfusion Analysis with Co-registered Hyperpolarized Gas and CE 1 H Perfusion MRI

Paul J.C. Hughes 1 , Bilal A. Tahir 1,2 , Felix C. Horn 1 , Helen Marshall 1 , Rob H. Ireland 1,2 , and James M. Wild 1

1 Academic Unit of Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Multi-nuclear lung MRI can provide high spatial resolution ventilation- and perfusion-weighted images, but these are normally acquired in different RF coils with the patient moved between acquisitions such that the ventilation and perfusion images are not spatially registered. This work proposes a semi-automated image processing workflow, including registration, masking and normalisation, for quantitative assessment of V/Q, and demonstrates its utility on images acquired from patients with moderate-to-severe asthma.

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