Abstract #1503
Rapid Tracheal Flow Measurements during Forced Inhalation and Exhalation
Kai Ruppert 1,2 , Bora Sul 3 , Kun Qing 2 , Vineet Rakesh 3 , Craig H Meyer 2 , John P Mugler III 2 , Anders Wallqvist 3 , Michael J Morris 4 , Talissa A Altes 2 , and Jaques Reifman 3
1
Cincinnati Children's Hospital, Cincinnati,
OH, United States,
2
University
of Virginia, Charlottesville, VA, United States,
3
Department
of Defense Biotechnology High Performance Computing
Software Applications Institute, United States Army
Medical Research and Materiel Command, Fort Detrick, MD,
United States,
4
Department
of Medicine, San Antonio Military Medical Center, Fort
Sam Houston, TX, United States
Attempts are underway to study airflow in the lungs
using computational fluid dynamics in order to
characterize disease-specific patterns. Flow-sensitive
hyperpolarized-gas MRI offers a unique opportunity for
experimental validation of such models in vivo. However,
so far, such studies have only been performed in the
slow-flow regime, which is believed to be less sensitive
to pathological changes. Using interleaved-spiral
acquisitions with a field-of-view only covering the
trachea, we were able in this feasibility study to
measure cross-sectional flow with a true temporal
resolution of 150 ms and a spatial in-plane resolution
of 0.8 mm during forced inspiration and expiration.
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