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Abstract #1503

Rapid Tracheal Flow Measurements during Forced Inhalation and Exhalation

Kai Ruppert 1,2 , Bora Sul 3 , Kun Qing 2 , Vineet Rakesh 3 , Craig H Meyer 2 , John P Mugler III 2 , Anders Wallqvist 3 , Michael J Morris 4 , Talissa A Altes 2 , and Jaques Reifman 3

1 Cincinnati Children's Hospital, Cincinnati, OH, United States, 2 University of Virginia, Charlottesville, VA, United States, 3 Department of Defense Biotechnology High Performance Computing Software Applications Institute, United States Army Medical Research and Materiel Command, Fort Detrick, MD, United States, 4 Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, TX, United States

Attempts are underway to study airflow in the lungs using computational fluid dynamics in order to characterize disease-specific patterns. Flow-sensitive hyperpolarized-gas MRI offers a unique opportunity for experimental validation of such models in vivo. However, so far, such studies have only been performed in the slow-flow regime, which is believed to be less sensitive to pathological changes. Using interleaved-spiral acquisitions with a field-of-view only covering the trachea, we were able in this feasibility study to measure cross-sectional flow with a true temporal resolution of 150 ms and a spatial in-plane resolution of 0.8 mm during forced inspiration and expiration.

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