Meeting Banner
Abstract #1502

Feasibility of hyperpolarized helium-3 MRI-guided bronchoscopic assessment of emergent ventilation defect regions in asthma

David G. Mummy 1 , Robert P. Thomen 2 , Stanley J. Kruger 3 , Alfonso Rodriguez 3 , Robert V. Cadman 3 , Nizar N. Jarjour 4 , Loren C. Denlinger 4 , Ronald L. Sorkness 4,5 , Mark L. Schiebler 6 , Jason C. Woods 7 , and Sean B. Fain 3,6

1 Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, 2 Physics, Washington University in St. Louis, St. Louis, MO, United States, 3 Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 4 Allergy, Pulmonary & Critical Care Medicine, Department of Medicine, University of Wisconsin - Madison, Madison, WI, United States, 5 Pharmacy, University of Wisconsin - Madison, Madison, WI, United States, 6 Radiology, University of Wisconsin - Madison, Madison, WI, United States, 7 Pediatrics, University of Cincinnati, Cincinnati, OH, United States

The progression of ventilation defects in asthma is poorly understood. Targeted longitudinal bronchoscopic sampling of lung segments exhibiting ventilation defects is of interest in characterizing physiological changes associated with defect development. Sampling that targets regions with emergent defects may detect acute local inflammatory response and changes in lung parenchyma. In this study, longitudinal hyperpolarized helium-3 MRI was used in conjunction with CT to identify regions of emergent defect in five asthma subjects. Anatomic levels of emergent defect were determined by lung segment. The results can facilitate targeted bronchoscopic sampling of ventilation defects in longitudinal studies of severe asthma.

This abstract and the presentation materials are available to members only; a login is required.

Join Here