Abstract #1502
Feasibility of hyperpolarized helium-3 MRI-guided bronchoscopic assessment of emergent ventilation defect regions in asthma
David G. Mummy 1 , Robert P. Thomen 2 , Stanley J. Kruger 3 , Alfonso Rodriguez 3 , Robert V. Cadman 3 , Nizar N. Jarjour 4 , Loren C. Denlinger 4 , Ronald L. Sorkness 4,5 , Mark L. Schiebler 6 , Jason C. Woods 7 , and Sean B. Fain 3,6
1
Biomedical Engineering, University of
Wisconsin - Madison, Madison, WI, United States,
2
Physics,
Washington University in St. Louis, St. Louis, MO,
United States,
3
Medical
Physics, University of Wisconsin - Madison, Madison, WI,
United States,
4
Allergy,
Pulmonary & Critical Care Medicine, Department of
Medicine, University of Wisconsin - Madison, Madison,
WI, United States,
5
Pharmacy,
University of Wisconsin - Madison, Madison, WI, United
States,
6
Radiology,
University of Wisconsin - Madison, Madison, WI, United
States,
7
Pediatrics,
University of Cincinnati, Cincinnati, OH, United States
The progression of ventilation defects in asthma is
poorly understood. Targeted longitudinal bronchoscopic
sampling of lung segments exhibiting ventilation defects
is of interest in characterizing physiological changes
associated with defect development. Sampling that
targets regions with emergent defects may detect acute
local inflammatory response and changes in lung
parenchyma. In this study, longitudinal hyperpolarized
helium-3 MRI was used in conjunction with CT to identify
regions of emergent defect in five asthma subjects.
Anatomic levels of emergent defect were determined by
lung segment. The results can facilitate targeted
bronchoscopic sampling of ventilation defects in
longitudinal studies of severe asthma.
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