Abstract #1506
Anatomical Distribution of Fractional Ventilation and Oxygen Uptake Imaged by Multibreath Wash-in Helium-3 MRI in Human Subjects
Hooman Hamedani 1 , Stephen Kadlecek 1 , Yi Xin 1 , Hoora Shaghaghi 1 , Sarmad Siddiqui 1 , Milton Rossman 2 , and Rahim R. Rizi 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Medicine,
University of Pennsylvania, Philadelphia, PA, United
States
The suite of imaged fractional ventilation and oxygen
tension may provide a useful diagnostic tool for the
detection and monitoring of subclinical smoking-related
alterations in lung function. Both fractional
ventilation and oxygen uptake gravity gradients
successfully differentiated between healthy non-smoker,
asymptomatic smoker, and COPD subjects. The results in
asymptomatic smokers also indicate that cigarette smoke
induces changes in the lung that are not being captured
by the clinical tests.
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