High SNR improves the repeatability of proton density fat fraction measurements in the liver
Utaroh Motosugi 1,2 , Diego Hernando 1 , Peter Bannas 1,3 , and Scott B. Reeder 1,4
Radiology, University of Wisconsin, Madison,
wisconsin, United States,
University of Yamanashi, Yamanashi, Japan,
University Hospital Hamburg-Eppendorf, Hamburg, Germany,
Physics, University of Wisconsin, Madison, wisconsin,
Quantitative chemical shift-encoded MRI (CSE-MRI) to
quantify proton density fat fraction (PDFF) is an
established and accurate imaging-based method to
quantify liver fat. CSE-MRI is accurate and reproducible
across different field strength and vendors. The
precision of PDFF determined using test/retest
measurements is approximately 35 percent points.
However, threshold values of ~5% are commonly used to
identify clinically significant fatty liver disease,
requiring improved precision. In this study, we
demonstrate that high SNR acquisition obtained through a
decrease in spatial resolution provides significantly
improved repeatability (precision) for PDFF measurements
in the liver.
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