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Abstract #1513

High SNR improves the repeatability of proton density fat fraction measurements in the liver

Utaroh Motosugi 1,2 , Diego Hernando 1 , Peter Bannas 1,3 , and Scott B. Reeder 1,4

1 Radiology, University of Wisconsin, Madison, wisconsin, United States, 2 Radiology, University of Yamanashi, Yamanashi, Japan, 3 Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, 4 Medical Physics, University of Wisconsin, Madison, wisconsin, United States

Quantitative chemical shift-encoded MRI (CSE-MRI) to quantify proton density fat fraction (PDFF) is an established and accurate imaging-based method to quantify liver fat. CSE-MRI is accurate and reproducible across different field strength and vendors. The precision of PDFF determined using test/retest measurements is approximately 35 percent points. However, threshold values of ~5% are commonly used to identify clinically significant fatty liver disease, requiring improved precision. In this study, we demonstrate that high SNR acquisition obtained through a decrease in spatial resolution provides significantly improved repeatability (precision) for PDFF measurements in the liver.

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