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Abstract #1512

Oral Lipid Challenge: The Effects of Saturated Fat on Hepatic Gluconeogenesis, ATP Production, and Fat Accumulation in Healthy Humans

Paul Begovatz 1 , Sabine Kahl 1,2 , Peter Nowotny 1 , Bettina Nowotny 1,2 , and Michael Roden 1,2

1 Leibniz Center for Diabetes Research at Heinrich Heine University, Institute for Clinical Diabetology, German Diabetes Center, Dsseldorf, Germany, 2 University Hospital, Department of Endocrinology and Diabetology, Dsseldorf, Germany

Healthy male volunteers (n=14, Age 25.65.3 yr, BMI of 22.51.1 kg/m 2 ) ingested a 1.20.1 g/(kg body weight) bolus of palm oil or placebo during a 20-hr fast. 13 C-MRS liver glycogen measurements revealed decreased rates of net glycogen breakdown, and increased gluconeogenesis during oil intervention compared to placebo. Palm oil intervention also led to increased rates of lipid oxidation (indirect calorimetry), and increased hepatic ATP production ( 31 P-MRS, 3D ISIS), and liver fat (single voxel 1 H-MRS). This provides evidence that a single oral bolus of saturated fat leads to increased gluconeogenesis through free fatty acid oxidation and ATP production in healthy subjects.

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