Abstract #1570
Visualization of Lupus Nephritis using SPIO
Ting Chen 1,2 , Yuki Mori 1,2 , Zhenyu Cheng 1,2 , Soyoung Lee 1 , Kai Wang 1 , Barry Ripley 1 , Tadamitsu Kishimoto 1 , Chizuko Inui-Yamamoto 1,2 , Fuminori Sugihara 1 , Noriko Kitagaki 1 , Yoshiyuki Tago 3 , Shinichi Yoshida 3 , Kohji Ohno 4 , and Yoshichika Yoshioka 1,2
1
Immunology Frontier Research Center (IFReC),
Osaka University, Suita, Osaka, Japan,
2
Center
for Information and Neural Networks (CiNet), National
Institute of Information and Communications Technology
(NICT) and Osaka University, Suita, Osaka, Japan,
3
Biotechnology
Development Laboratories, Kaneka Corporation, Takasago,
Hyogo, Japan,
4
Institute
for Chemical Research, Kyoto University, Uji, Kyoto,
Japan
a new contrast agent containing anti-Sm antibody was
generated for visualizing the Lupus Nephritis
in-vivo,the specific distribution pattern of it in the
renal corpuscle may reflect the symptoms of kidney
disease in SLE model mice, and it also showed us the
possibility of diagnosing the SLE by this new particle.
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