Accurate quantification of blood perfusion in the kidney using pseudo-continuous arterial spin labelling: an optimisation and reproducibility study

The measurement of blood perfusion in the kidney using a non-contrast approach was investigated. A protocol was optimised using pseudo-continuous arterial spin labelling coupled with a TSE readout, and the reproducibility of the resulting measurements assessed in a healthy cohort. A spatial resolution of 2.5x2.5x6mm3 was obtained with an SNR of 563, allowing for separation of cortex and medulla regions in the calculated perfusion maps. Mean perfusion values of 29344 / 13920 ml/100g/min were measured in the cortex/medulla respectively, with good intra- and inter-session reproducibility. Good breath-hold tolerance reported by the volunteers suggests that clinical implementation is feasible.

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