Application of mathematical modelling to a DCE-MRI phantom: predicting the shape of contrast agent uptake curves.
Laura Smith 1 , Marco Borri 1 , Araminta EW Ledger 1 , Craig Cummings 1 , Maria A Schmidt 1 , and Martin O Leach 1
CR-UK Cancer Imaging Centre, Sutton, Surrey,
In previous work we reported a novel DCE-MRI test object
of simple and affordable design, which can create
reproducible uptake curves. In this work we demonstrate
that it is possible to derive a series of simple, smooth
transfer functions which describe the evolution of the
contrast agent uptake curve along the dynamic test
object. Furthermore, the derived transfer functions were
validated: they were able to predict the experimental
curves at different locations within the test object in
a series of experiments with different input functions.
This abstract and the presentation materials are available to members only;
a login is required.