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Abstract #1590

Application of mathematical modelling to a DCE-MRI phantom: predicting the shape of contrast agent uptake curves.

Laura Smith 1 , Marco Borri 1 , Araminta EW Ledger 1 , Craig Cummings 1 , Maria A Schmidt 1 , and Martin O Leach 1

1 CR-UK Cancer Imaging Centre, Sutton, Surrey, United Kingdom

In previous work we reported a novel DCE-MRI test object of simple and affordable design, which can create reproducible uptake curves. In this work we demonstrate that it is possible to derive a series of simple, smooth transfer functions which describe the evolution of the contrast agent uptake curve along the dynamic test object. Furthermore, the derived transfer functions were validated: they were able to predict the experimental curves at different locations within the test object in a series of experiments with different input functions.

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