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Abstract #1591

Assessment of system linearity and response to input parameters in a Dynamic Contrast-Enhanced (DCE) MRI phantom

Laura Smith 1 , Araminta EW Ledger 1 , Marco Borri 1 , Craig Cummings 1 , Maria A Schmidt 1 , and Martin O Leach 1

1 CR-UK Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

There is a need to prospectively assess the effect of parameter alterations on contrast agent (CA) uptake curves in DCE-MRI protocols. This abstract investigates the behaviour of a novel and inexpensive phantom, designed to create reproducible CA uptake curves for quality assurance (QA) of DCE-MRI sequences. Here we establish the linear behaviour of the phantom and demonstrate that alteration of input parameters produces predictable variation in CA uptake curves. A tuneable reference CA uptake curve will be a valuable QA tool and can be used to investigate the effect of parameter variation on CA uptake curves in DCE-MRI protocols.

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