Abstract #1591
Assessment of system linearity and response to input parameters in a Dynamic Contrast-Enhanced (DCE) MRI phantom
Laura Smith 1 , Araminta EW Ledger 1 , Marco Borri 1 , Craig Cummings 1 , Maria A Schmidt 1 , and Martin O Leach 1
1
CR-UK Cancer Imaging Centre, The Institute
of Cancer Research and Royal Marsden NHS Foundation
Trust, Sutton, Surrey, United Kingdom
There is a need to prospectively assess the effect of
parameter alterations on contrast agent (CA) uptake
curves in DCE-MRI protocols. This abstract investigates
the behaviour of a novel and inexpensive phantom,
designed to create reproducible CA uptake curves for
quality assurance (QA) of DCE-MRI sequences. Here we
establish the linear behaviour of the phantom and
demonstrate that alteration of input parameters produces
predictable variation in CA uptake curves. A tuneable
reference CA uptake curve will be a valuable QA tool and
can be used to investigate the effect of parameter
variation on CA uptake curves in DCE-MRI protocols.
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