Abstract #1595
MRI/S Assessment of Cardiac Morphology/Function and Skeletal Muscle Energetics in Mitochondrial DNA Mutated Mice
Hasan Alsaid 1 , Mary V Rambo 1 , Tinamarie Skedzielewski 1 , Ruth R Osborn 2 , Alicia M Davis M Davis 2 , William Rumsey 2 , and Beat M Jucker 1
1
Preclinical & Translational Imaging, LAS,
PTS, GlaxoSmithKline, King of Prussia, PA, United
States,
2
Stress
Repair DPU, Respiratory TAU, GlaxoSmithKline, King of
Prussia, PA, United States
In this study, we assessed cardiac morphology/function
and skeletal muscle energetics in mitochondrial DNA
mutated PolG mice (Polymerase gamma-deficient) that had
been either exposed to cigarette smoke, forced air, or
room air for 5 months. Skeletal muscle energetic
compromise was observed in the PolG mice. Initial stages
of heart failure appears to be present in the PolG mice
compared to the wild type mice as reflected by the lef
ventricular chamber dilation and the increase in the
normalized lef ventricular mass to body weight. Cardiac
function is still preserved in all groups. No
differences in gender or smoke exposure were found
between groups.
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