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Abstract #1595

MRI/S Assessment of Cardiac Morphology/Function and Skeletal Muscle Energetics in Mitochondrial DNA Mutated Mice

Hasan Alsaid 1 , Mary V Rambo 1 , Tinamarie Skedzielewski 1 , Ruth R Osborn 2 , Alicia M Davis M Davis 2 , William Rumsey 2 , and Beat M Jucker 1

1 Preclinical & Translational Imaging, LAS, PTS, GlaxoSmithKline, King of Prussia, PA, United States, 2 Stress Repair DPU, Respiratory TAU, GlaxoSmithKline, King of Prussia, PA, United States

In this study, we assessed cardiac morphology/function and skeletal muscle energetics in mitochondrial DNA mutated PolG mice (Polymerase gamma-deficient) that had been either exposed to cigarette smoke, forced air, or room air for 5 months. Skeletal muscle energetic compromise was observed in the PolG mice. Initial stages of heart failure appears to be present in the PolG mice compared to the wild type mice as reflected by the lef ventricular chamber dilation and the increase in the normalized lef ventricular mass to body weight. Cardiac function is still preserved in all groups. No differences in gender or smoke exposure were found between groups.

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