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Abstract #1596

Safeguarding the Family Jewels: Using MRI to Monitor for Testicular Toxicity

Denise Welsh-McCracken 1 , Yvonne Van Gessel 1 , Dierdre Scully 2 , Jacob Hesterman 2 , and Paul J McCracken 1

1 Eisai, Andover, MA, United States, 2 InviCRO, Boston, MA, United States

Drug induced testicular toxicity creates a potential obstacle to moving promising new therapies into clinical trials. We investigate the utility MRI for detecting and monitoring testicular toxicity in a rat pilot study. Mild toxicity was induced in mature male SD rats using 1,3 Dinitrobenzene (35mpk po). Rats were imaged on days 0, 3,5, and 15. T2-weighted image data were bias-field corrected and manually segmented to isolate the testes signal. 2D fast Fourier transform (FFT) was used to map data to the spatial frequency domain. Fourier analysis revealed decreased group average AUCs at days 3 and 5, reaching significance at day15.

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