Meeting Banner
Abstract #1598

B0 inhomogeneity correction of T2* from fat-water MRI: application to a diet-induced obesity mouse model at 15.2T

Henry H. Ong 1,2 , Corey D. Webb 3 , Marnie L. Gruen 3 , Alyssa H. Hasty 3 , John C. Gore 1,2 , and E. Brian Welch 1,2

1 Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3 Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, United States

Previously, we investigated the potential of T2* estimated from quantitative fat-water MRI (FWMRI) as a marker of adipose tissue inflammatory changes due to adipocyte iron overload in an established diet-induced obesity mouse model at 15.2T. Preliminary results indicated presence of large background B0 variations (50-250 Hz/mm) that could adversely affect T2* mapping. Here, we implement a recently proposed B0 variation correction of FWMRI data. Using a subset of our previous data, we show feasibility of this correction method for in vivo mouse data at 15.2T. The correction primarily affects T2* and not fat-signal-fraction or Capital Greek Delta B0 in agreement with previous reports.

This abstract and the presentation materials are available to members only; a login is required.

Join Here