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Abstract #1602

Clinical feasibility of time-dependent diffusion MRI for improved prostate cancer grading

Gregory Lemberskiy 1,2 , Dmitry S Novikov 1 , Henry Rusinek 1 , Els Fieremans 1 , and Andrew Rosenkrantz 1

1 Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 2 Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States

Synopsis: Time-dependent diffusion can be used to distinguish populations of low grade/high grade and benign tissue in prostate tissue. We found that peripheral zone experiences transient time-dependence, while tumors have a constant dependence in the same range. Adding time-dependent ADC acquisitions for such analysis is clinically feasible as it costs ~7 minutes without the use of state of the art acceleration techniques.

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