Abstract #1603
A Spatially Constrained Probability Distribution Model of Incoherent Motion (SPIM) in Quantitative Diffusion Weighted MRI
Sila Kurugol 1 , Moti Freiman 1 , Onur Afacan 1 , and Simon K Warfield 1
1
Radiology, Boston Children's Hospital and
Harvard Medical School, Boston, Massachusetts, United
States
Quantitative diffusion-weighted MRI (DW-MRI) is
well-established role in characterization of
abnormalities including liver fibrosis and tumors.
Diffusion of molecules leads to attenuation in the
diffusion signal measured at multiple b-values. This
attenuation has slow and fast components associated with
diffusion and microcirculation, represented by
bi-exponential model of the intravoxel incoherent motion
(IVIM). Fast diffusion can occur over a large range of
length and time scales. In this work, we introduce a
spatially-constrained two-component probability mixture
model of diffusion (SPIM) for the precise
characterization of the multi-scale heterogeneous
diffusion. We compare the SPIM model with the IVIM in 68
abdominal DW-MRIs.
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