A Spatially Constrained Probability Distribution Model of Incoherent Motion (SPIM) in Quantitative Diffusion Weighted MRI

Quantitative diffusion-weighted MRI (DW-MRI) is well-established role in characterization of abnormalities including liver fibrosis and tumors. Diffusion of molecules leads to attenuation in the diffusion signal measured at multiple b-values. This attenuation has slow and fast components associated with diffusion and microcirculation, represented by bi-exponential model of the intravoxel incoherent motion (IVIM). Fast diffusion can occur over a large range of length and time scales. In this work, we introduce a spatially-constrained two-component probability mixture model of diffusion (SPIM) for the precise characterization of the multi-scale heterogeneous diffusion. We compare the SPIM model with the IVIM in 68 abdominal DW-MRIs.

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