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Abstract #1609

Diffusion-weighted Imaging using a Statistical Model as a Functional MRI of the Kidney: Preliminary Experience

Kentaro Yamada 1 , Hiroshi Shinmoto 1 , Seigo Ito 2 , Hiroo Kumagai 2 , Tatsumi Kaji 1 , and Koichi Oshio 3

1 Radiology, National Defense Medical College, Tokorozawa, Saitama, Japan, 2 Nephrology and Endocrinology, National Defense Medical College, Saitama, Japan, 3 Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan

The purpose of this study was to evaluate the appropriateness of diffusion-weighted imaging (DWI) using a statistical model based on a truncated-Gaussian distribution for diffusion signal decays of the kidney and their correlation with renal function. Nineteen patients with renal diseases and 13 healthy volunteers were included. DWI was performed using five b-values (0, 500, 1000, 1500, and 2000). The statistical model yielded a statistically better fit compared to the mono-exponential model (P<0.01). Fraction of ADC<1.0 (%) showed good correlation with renal function. This model might aid in interpreting diffusion MR signals related to histological changes in the kidney.

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