Abstract #1622
Effect of Weight Loss and Regional Differences in Abdominal Adipose Tissue Hydration
Suresh Anand Sadananthan 1 , Navin Michael 1 , Eric Yin Hao Khoo 2 , Melvin Khee-Shing Leow 1,3 , Chin Meng Khoo 2 , Kavita Venkataraman 4 , Yung Seng Lee 1,5 , Yap Seng Chong 1,6 , Peter D. Gluckman 1 , E. Shyong Tai 2 , and S. Sendhil Velan 7,8
1
Singapore Institute for Clinical Sciences,
A*STAR, Singapore,
2
Department
of Medicine, Yong Loo Lin School of Medicine, National
University of Singapore, Singapore,
3
Department
of Endocrinology, Tan Tock Seng Hospital, Singapore,
4
Saw
Swee Hock School of Public Health, National University
of Singapore, Singapore,
5
Department
of Paediatrics, Yong Loo Lin School of Medicine,
National University of Singapore, Singapore,
6
Department
of Obstetrics & Gynaecology, Yong Loo Lin School of
Medicine, National University of Singapore, Singapore,
7
Singapore
BioImaging Consortium, A*STAR, Singapore,
8
Clinical
Imaging Research Centre, A*STAR, Singapore
Weight loss alters the levels of liver, muscle and
abdominal fat and also results in increased insulin
sensitivity. Earlier studies using indirect measurements
of subcutaneous adipose tissue water content have shown
increase in the water content following weight loss
intervention. Reduced water content is strongly
associated with hypertrophic expansion of the adipose
tissue. In this study, we have investigated the use of
1
H
MRS to noninvasively quantify the changes in adipose
tissue water content with weight loss intervention.
Furthermore, we have looked at the regional differences
in the water content in DSAT, SSAT and VAT depots pre-
and post-intervention.
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