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Abstract #1623

Visualizing and quantifying human fat digestion with IDEAL

Dian Liu 1 , Helen Louise Parker 2 , Jelena Curcic 1,2 , Sebastian Kozerke 1 , and Andreas Steingoetter 1,2

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2 Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland

This study uses chemical shift-encoded imaging by IDEAL to visualize and quantify the influence of intragastric stability of fat emulsions on the dynamics and structure of gastric luminal content and the related fat emptying into the duodenum. The different intragastric stability of the emulsions resulted in different structuring of intraluminal content and different emptying patterns, which resulted in bi-phasic and significantly faster emptying of gastric content and highly variable gastric and duodenal fat fractions for the acid unstable emulsion. No temporal effect was detected for duodenal content volume or fat fraction between the emulsions.

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