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Abstract #1634

MRI-Guided Transurethral Ultrasound Therapy of the Prostate Gland using Real-Time Thermal Mapping: An Analysis of Technical Accuracy and Immediate Postinterventional Assessment of Tissue Destruction via CE-MRI

Maya Barbara Mller-Wolf 1 , Mathieu Burtnyk 2 , Valentin Ionel Popeneciu 3 , Gencay Hatiboglu 3 , Michele Billia 4 , Cesare Romagnoli 5 , Joseph Chin 4 , Sascha Pahernik 3 , Heinz-Peter Schlemmer 6 , and Matthias C Roethke 1

1 Radiology, German Cancer Research Center, Heidelberg, Baden-Wuerttemberg, Germany, 2 Profound Medical, Toronto, Ontario, Canada, 3 Urology, University Hospital Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany, 4 Urology, Western University UWO London Victoria Hospital, London, Ontario, Canada, 5 Radiology, Western University UWO London Victoria Hospital, London, Ontario, Canada, 6 Radiology, German Cancer Research Center, Baden-Wuerttemberg, Germany

Local disease control and low morbidity are goals of minimally-invasive, image-guided therapies for localised prostate cancer. MRI-guided transurethral ultrasound ablation constitutes an attractive treatment alternative to active surveillance and radical treatments. Real-time MR-thermometry and active temperature feedback control enable assessment of treatment success through thermal dosimetry and visualization of immediate post-interventional contrast-enhanced MRI. A prospective phase I trial was conducted to determine targeting accuracy of conformal heating to predefined acute ablation boundary (T2-planning) using linear and volumetric metrics including Dice Similarity Coefficient. Thermal coagulation was confirmed by visually comparing the MR-thermometry images to the non-perfused volume on CE-MRI.

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