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Abstract #1635

MR imaging for the evaluation of boiling histotripsy treatment or thermal High Intensity Focused Ultrasound treatment in mouse lymphoma

Martijn Hoogenboom 1 , Dylan Eikelenboom 2 , Martijn H den Brok 2 , Erik Dumont 3 , Gosse J Adema 2 , Arend Heerschap 1 , and Jurgen J Futterrer 1,4

1 Department of Radiology and Nuclear medicine, Radboud University Medical Center, Nijmegen, Gelderland, Netherlands, 2 Department of Tumor Immunology, Radboud University Medical Center, Nijmegen, Gelderland, Netherlands, 3 Image Guided Therapy, Pessac, France, 4 MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, Netherlands

Boiling histotripsy is a focal ablation technique for fragmentation of the tissue using high intensity focused ultrasound. Until now ultrasound imaging is used for guidance of the treatment. This study shows MR guided HIFU treatment (boiling histotripsy and thermal ablation) with different MR response imaging techniques (T2w, PD, T1w, DCE) to evaluate the lesion immediately after treatment in mouse tumors. It is shown that immediately after boiling histotripsy a hyperintense lesion is visualized on T2w imaging which highly correlates with sharp delineated liquefied lesion found on pathologic slices. No contrast enhancement is measured within the lesion using DCE imaging.

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