Abstract #1635
MR imaging for the evaluation of boiling histotripsy treatment or thermal High Intensity Focused Ultrasound treatment in mouse lymphoma
Martijn Hoogenboom 1 , Dylan Eikelenboom 2 , Martijn H den Brok 2 , Erik Dumont 3 , Gosse J Adema 2 , Arend Heerschap 1 , and Jurgen J Futterrer 1,4
1
Department of Radiology and Nuclear
medicine, Radboud University Medical Center, Nijmegen,
Gelderland, Netherlands,
2
Department
of Tumor Immunology, Radboud University Medical Center,
Nijmegen, Gelderland, Netherlands,
3
Image
Guided Therapy, Pessac, France,
4
MIRA
Institute for Biomedical Technology and Technical
Medicine, University of Twente, Enschede, Overijssel,
Netherlands
Boiling histotripsy is a focal ablation technique for
fragmentation of the tissue using high intensity focused
ultrasound. Until now ultrasound imaging is used for
guidance of the treatment. This study shows MR guided
HIFU treatment (boiling histotripsy and thermal
ablation) with different MR response imaging techniques
(T2w, PD, T1w, DCE) to evaluate the lesion immediately
after treatment in mouse tumors. It is shown that
immediately after boiling histotripsy a hyperintense
lesion is visualized on T2w imaging which highly
correlates with sharp delineated liquefied lesion found
on pathologic slices. No contrast enhancement is
measured within the lesion using DCE imaging.
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