Abstract #1637
Targeting Effects on the Volume and Gray-To-White-Matter Ratio of the Focused-Ultrasound Induced Blood-Brain Barrier Opening in Non-Human Primates In Vivo
Maria Eleni Karakatsani 1 , Gesthimani Samiotaki 1 , Matthew Downs 1 , Vincent Ferrera 2 , and Elisa Konofagou 1,3
1
Department of Biomedical Engineering,
Columbia University, New York, NY, United States,
2
Department
of Neuroscience, Columbia University, New York, NY,
United States,
3
Department of Radiology,
Columbia University, New York, NY, United States
The application of focused ultrasound (FUS) coupled with
the systemic administration of microbubbles has been
proved to open the Blood-Brain Barrier locally,
transiently and non-invasively in non-human primates.
This study provides evidence for a linear correlation
between the incidence angle, the FUS pressure and the
induced opening size. The parametric optimization of the
experimental setup inducing the desired opening and the
reproducibility of the experiment are achieved. Results
also indicate that the opening-to-targeting-shift is
gray-to-white-matter ratio dependent. For both tasks 3D
T1 weighted pre- and post-contrast images were acquired
based on which an automated intensity-based algorithm
was designed.
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