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Abstract #1638

Correlation of Lesion Size to Thermal Dose Measured by MR Thermometry in MR-Guided Focused Ultrasound for the Treatment of Essential Tremor

Yuexi Huang 1 , Nir Lipsman 2 , Michael L. Schwartz 3 , Vibhor Krishna 2 , Francesco Sammartino 2 , Andres M. Lozano 2 , and Kullervo Hynynen 1,4

1 Sunnybrook Research Institute, Toronto, ON, Canada, 2 Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada, 3 Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4 Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Magnetic resonance guided focused ultrasound has shown promising results in the treatment of essential tremor. MR temperature and thermal dose measurement plays a crucial role in monitoring and guiding acoustic parameters. In general, the size of the lesion can be detected by MR imaging immediately after the treatment is significantly smaller than the size on the following day while the lesion continues to develop over hours. Therefore, it would be useful if thermal dose can be used to predict the ultimate lesion size and thus determine the end point of the treatment. In this study, we correlated the size of the thermal dose to the lesion size at the follow-up imaging on the second day and found the lesion sizes were between 240 and 17 EM thermal doses.

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