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Abstract #1646

Comparison of Multi-contrast MRI for Characterization of Irreversible Electroporation Ablation Zones in a Pig Liver Model with Histopathologic Correlation

Isabel Dregely 1 , Kyung Sung 1 , Ferdnand Osuagwu 1 , Dong Jin Chung 1 , Charles Lassman 2 , David Lu 1 , and Holden H Wu 1

1 Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2 Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, United States

Irreversible electroporation (IRE) is a new technique for minimally invasive local tissue ablation. Multi-contrast MRI has potential to non-invasively monitor IRE procedures. The purpose of this study was to evaluate multi-contrast (T2w, T1w pre and post contrast agent, and diffusion weighted imaging (DWI)) MRI for characterizing tissue ablation zones created by irreversible electroporation (IRE) in normal pig liver and correlate with histopathology. We found that IRE ablation zones were clearly visualized with multiple MRI contrasts and lesion short axis from both T2w and T1w MRI were correlated with pathology.

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