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Abstract #1645

A combined interventional high-resolution targeted ablation, thermometry and imaging probe

M.Arcan Erturk 1,2 , Shashank Sathyanarayana Hegde 1 , and Paul A Bottomley 1

1 Radiology, Johns Hopkins University, Baltimore, Maryland, United States, 2 Center for Magnetic Resonance Research, University of Minnesota Medical School, Minnesota, United States

We demonstrate a single interventional antenna that combines high-resolution image-guided targeting, RF ablation therapy, high-resolution thermometry, and quantitative relaxation time mapping. Standard, thermometric, and quantitative T 1 and T 2 MRI were performed in tissue samples in vitro and a rabbit in vivo, before and after ablation using a 3T loopless antenna. Spatial resolution was 200-300m with 6-8s temporal resolution for thermometry. During ablation, the probe delivered local heating of >85C resulting in irreversible thermal injury and up to two-fold changes in relaxation times post-ablation. The device could serve as a complete detection, thermal therapy and monitoring vehicle for MRI-guided intervention.

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