Abstract #1645
A combined interventional high-resolution targeted ablation, thermometry and imaging probe
M.Arcan Erturk 1,2 , Shashank Sathyanarayana Hegde 1 , and Paul A Bottomley 1
1
Radiology, Johns Hopkins University,
Baltimore, Maryland, United States,
2
Center
for Magnetic Resonance Research, University of Minnesota
Medical School, Minnesota, United States
We demonstrate a single interventional antenna that
combines high-resolution image-guided targeting, RF
ablation therapy, high-resolution thermometry, and
quantitative relaxation time mapping. Standard,
thermometric, and quantitative T
1
and
T
2
MRI
were performed in tissue samples in vitro and a rabbit
in vivo, before and after ablation using a 3T loopless
antenna. Spatial resolution was 200-300m with 6-8s
temporal resolution for thermometry. During ablation,
the probe delivered local heating of >85C resulting in
irreversible thermal injury and up to two-fold changes
in relaxation times post-ablation. The device could
serve as a complete detection, thermal therapy and
monitoring vehicle for MRI-guided intervention.
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