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Abstract #1682

B 1 + Field Mapping Improves Accuracy of T 1 Measurements in Phantoms and Normal Breast at 3.0 T

Jennifer G. Whisenant 1 , Lori R. Arlinghaus 1 , Richard D. Dortch 1 , William A. Grissom 1 , Gregory S. Karczmar 2 , and Thomas E. Yankeelov 1

1 Vanderbilt University, Nashville, TN, United States, 2 University of Chicago, Chicago, IL, United States

This study evaluated the effect of B 1 + correction on T 1 measurements calculated from variable flip angle (VFA) data in phantoms and in vivo . Additionally, the accuracy of these measurements was compared to T 1 values from inversion recovery (IR) data. On average, 31% error was observed between IR and uncorrected VFA data in both phantoms and in vivo, which was significantly reduced to 6% (P<0.001) when applying a B 1 + correction. IR measurements of T 1 are very robust, yet the long acquisition times limit clinical utility. Therefore, these data suggest that the VFA method with B 1 + correction is a suitable alternative.

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