Exponential T2 Fitting with Even Echoes Only or Skipping the First Echo: How Well Does it Work?

It is common for researchers to skip the first echo, or skip all odd echoes in the echo train in order to determine T2 from exponential fitting multi-echo spin echo data. Using both simulations and in vivo experiments of slice selective muti-echo spin echo experiments, we find that these alternate exponential fitting schemes do not avoid T2-misestimation. Skipping the first echo may reduce errors to less than 10%, if very wide refocusing pulses are used, provided that the refocusing angles are >150 degrees.

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