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Abstract #1684

Proton density mapping: Removing receive-inhomogeneity using multi-coil information and T1 regularization

Aviv Mezer 1 , Ariel Rokem 2 , Trevor Hastie 2 , and Brian Wandell 2

1 Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, Israel, 2 Stanford university, CA, United States

Proton density is the most basic MRI measure, representing the amount of water protons in each voxel. Water content differs between tissue types, and changes during development and in disease. Using simulation we find that in the presence of noise, combining parallel imaging, smoothness assumptions, and the biophysical regularization together generates the most accurate estimates of both coil sensitivity maps and PD. We confirm the high accuracy when using multiple coils and T1-regularization on data from a phantom and a living human brain.

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