Abstract #1694
Rapid calculation of correction parameters to compensate for imperfect RF spoiling in quantitative R1 mapping
Martina F. Callaghan 1 , Shaihan J Malik 2 , and Nikolaus Weiskopf 1
1
Wellcome Trust Centre for Neuroimaging, UCL
Institute of Neurology, London, London, United Kingdom,
2
Division
of Imaging Sciences and Biomedical Engineering, King's
College London, London, United Kingdom
Quantitative MRI is attractive because of its
standardised nature and higher specificity to underlying
tissue microstructure. Acquiring spoiled gradient echo
datasets with two different flip angles is an efficient
approach to mapping the longitudinal relaxation rate
with high resolution and whole brain coverage. However,
this approach is biased when the transverse
magnetisation is not fully spoiled. Correcting this
effect relies on simulating the steady state signal
taking account of the full suite of sequence parameters,
including diffusion effects. Long simulations need to be
recomputed for every sequence change. Here we
demonstrate a rapid alternative using the extended phase
graph approach.
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