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Abstract #1694

Rapid calculation of correction parameters to compensate for imperfect RF spoiling in quantitative R1 mapping

Martina F. Callaghan 1 , Shaihan J Malik 2 , and Nikolaus Weiskopf 1

1 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, London, United Kingdom, 2 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Quantitative MRI is attractive because of its standardised nature and higher specificity to underlying tissue microstructure. Acquiring spoiled gradient echo datasets with two different flip angles is an efficient approach to mapping the longitudinal relaxation rate with high resolution and whole brain coverage. However, this approach is biased when the transverse magnetisation is not fully spoiled. Correcting this effect relies on simulating the steady state signal taking account of the full suite of sequence parameters, including diffusion effects. Long simulations need to be recomputed for every sequence change. Here we demonstrate a rapid alternative using the extended phase graph approach.

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