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Abstract #1695

Performing Dynamic Contrast-Enhanced MRI quality assurance for multi-centre trials using a multi-compartment phantom with physiological T1s

Neil Peter Jerome 1 , Vasia Papoutsaki 1 , James A d'Arcy 1 , Harold G Parkes 1 , Nandita deSouza 1 , Martin O Leach 1 , and David J Collins 1

1 Radiotherapy & Imaging, The Institute of Cancer Research, Sutton, London, United Kingdom

The inclusion of Dynamic Contrast Enhanced MRI into clinical trials, in particular those run across multiple centres, requires that quality assurance be performed, ensuring that functional parameters derived from different scanners may be usefully combined and compared. For DCE, the stability and noise characteristics are useful metrics for comparison; we present data from a multi-compartment test object with physiological T1s that allow comparison of DCE protocols with varying flip angles, as well as the same protocol acquired at two separate scanners, and demonstrate the usefulness of the test object for quality assurance of DCE-MRI.

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