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Abstract #1716

Ferumoxytol-enhanced Plural Contrast Imaging of the Human Brain

Samantha J Holdsworth 1 , Thomas Christen 1 , Kristen Yeom 1 , Jae Mo Park 1 , Greg Zaharchuk 1 , and Michael E Moseley 1

1 Department of Radiology, Stanford University, Stanford, CA, United States

In the present study, we generate multiple contrast mechanisms following the injection of Ferumoxytol (an FDA-approved ultra-small paramagnetic iron oxide [USPIO] compound) in the pediatric brain. The high magnetic susceptibility of ferumoxytol and its long halflife allows the acquisition of high quality/high spatial resolution 3D ME-GRE images in only 5:44-minutes and subsequent generation of R2* maps, field maps, Susceptibility-Weighted Imaging (SWI), Time-of-Flight (TOF), and Quantitative Susceptibility Maps (QSM).

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