Anatomically dependent variations in magnetic susceptibility produces spectral asymmetries in high spectral and spatial resolution MRI of post-mortem mouse brain
Sean Foxley 1 , Miriam Domowicz 2 , Nancy Schwartz 2 , and Gregory S Karczmar 3
FMRIB Centre, University of Oxford, Oxford,
OXON, United Kingdom,
of Pediatrics, University of Chicago, Illinois, United
of Radiology, University of Chicago, Illinois, United
Post-mortem mouse brain was imaged using high spectral
and spatial resolution MRI. This differs from more
conventional susceptibility weighted imaging approached
because a water spectrum is produced for each image
voxel. Specifically, the FID was sampled in 50x50x70
micron resolution voxels and Fourier transformed to
produce water spectra with 3.5 Hz spectral resolution.
Waterline asymmetries specific to deep white matter
tracts as well as between differing layers of the
cerebellum were observed. This indicates that differing
microstructurally driven susceptibilities are producing
varying resonances in a single voxel, which are
detectable using this approach.
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