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Abstract #1721

Anatomically dependent variations in magnetic susceptibility produces spectral asymmetries in high spectral and spatial resolution MRI of post-mortem mouse brain

Sean Foxley 1 , Miriam Domowicz 2 , Nancy Schwartz 2 , and Gregory S Karczmar 3

1 FMRIB Centre, University of Oxford, Oxford, OXON, United Kingdom, 2 Department of Pediatrics, University of Chicago, Illinois, United States, 3 Department of Radiology, University of Chicago, Illinois, United States

Post-mortem mouse brain was imaged using high spectral and spatial resolution MRI. This differs from more conventional susceptibility weighted imaging approached because a water spectrum is produced for each image voxel. Specifically, the FID was sampled in 50x50x70 micron resolution voxels and Fourier transformed to produce water spectra with 3.5 Hz spectral resolution. Waterline asymmetries specific to deep white matter tracts as well as between differing layers of the cerebellum were observed. This indicates that differing microstructurally driven susceptibilities are producing varying resonances in a single voxel, which are detectable using this approach.

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