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Abstract #1722

Quantification of Labeled Cell Clusters in a Rat Brain In Vivo Using MRI

Paul Kokeny 1 , Xie He 2 , Saifeng Liu 3 , Ching-Yi Hsieh 4 , Quan Jiang 5,6 , Yu-Chung Norman Cheng 1 , and E. Mark Haacke 1,4

1 School of Biomedical Engineering, Wayne State University, Detroit, MI, United States, 2 School of Physics, Wayne State University, Detroit, MI, United States, 3 School of Biomedical Engineering, McMaster Univeristy, Hamilton, Ontario, Canada, 4 Department of Radiology, Wayne State University, Detroit, MI, United States, 5 Department of Neurology, Henry Ford Health System, Detroit, MI, United States, 6 Department of Radiology, Henry Ford Health System, Detroit, MI, United States

Currently, the tracking of nanoparticle labeled cells via MRI is a qualitative process. However, given the magnetic moment of a labeled cell cluster along with the mass magnetization of the labeling agent and the average cellular iron uptake, it is possible to estimate the number of cells present in a cluster in vivo. In this work, the magnetic moments of six labeled cell clusters are quantified using a complex summation method that is accurate for small objects. The effect of high-pass filtering is analyzed through simulations. From these results, the number of cells present in each cluster is estimated.

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